Interfering Breast Cancer Metastases by Blocking NGAL Function PRINCIPAL INVESTIGATOR:
نویسنده
چکیده
Lipocalin 2 (LCN2, also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear. Here, we employed a spontaneous mammary tumor mouse model showing that MMTV-ErbB2(V664E) mice lacking of mLCN2 had significantly delayed mammary tumor formation and metastasis with reduced MMP-9 activity in the blood. LCN2 expression is upregulated by HER2/PI-3 kinase/AKT/NF-κB pathway. Decreasing LCN2 expression significantly reduced the invasion and migration ability of HER2 breast cancer cells. Furthermore, injecting an anti-mLCN2 antibody into mice bearing established murine breast tumors resulted in significant blockage of lung metastasis. Our findings indicate that LCN2 is a critical factor in enhancing breast tumor formation and progression, possibly in part by stabilizing MMP-9. Our results suggest that inhibition of LCN2 function by an inhibitory
منابع مشابه
Novel Approaches to Breast Cancer Prevention and Inhibition of Metastases PRINCIPAL INVESTIGATOR:
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TITLE: Effect of a High Bone Turnover State Induced by Estrogen Deficiency on the Development and Progression of Breast Cancer Bone Metastases PRINCIPAL INVESTIGATOR:
s: 1.Abstract (poster) from the Skeletal Complications of Malignancy IV Meeting; April 2005; Bethesda, MD: Aromatase Inhibition Results in Lower Bone Density Than Ovariectomy in Mice an Effect Prevented by Bisphosphonates. W.M. Kozlow, K. Mohammad, R. McKenna, M. Niewolna and T.A. Guise. Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, USA.
متن کاملInhibition of lipocalin 2 impairs breast tumorigenesis and metastasis.
Lipocalin 2 (LCN2; also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear. Here, we employed a spontaneous mammary tumor mouse model showing that MMTV-ErbB2(V664E) mice lacking mouse LCN2 had significantly delayed mammary tumor formation and metastasis with reduced matrix ...
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